Typifying the atypical parathyroid adenoma

Parathyroid carcinoma, atypical parathyroid adenoma, or parathyromatosis?

BACKGROUND Parathyroid carcinoma, atypical parathyroid adenoma, and parathyromatosis can be differentiated relatively easily from typical parathyroid adenomas, but distinguishing them from each other is more difficult. METHODS A retrospective study of 28 consecutive patients with parathyroid carcinoma, 7 patients with atypical parathyroid adenoma, and 13 patients with parathyromatosis who wer...

Her Aching Bones: Atypical Parathyroid Adenoma.

Atypical parathyroid adenoma with diffuse fibrosis.

Parathyroid adenomas are benign encapsulated neoplasms that are typically comprised of chief cells and feature a rim of normal parathyroid tissue at their periphery. A small subset can be classified as atypical based on the presence of some histologic features of malignancy, such as a trabecular growth pattern, increased mitotic activity, capsular invasion, and fibrous bands, without definitive...

Association between atypical parathyroid adenoma and neurofibromatosis.

Primary hyperparathyroidism is a disease characterized by excessive production of parathyroid hormone (PTH), which is due to a parathyroid adenoma in 85% of cases. An atypical parathyroid adenoma, with some histopathological features of parathyroid carcinoma, may be found in some of the cases, although it may not fulfill all the criteria for this diagnosis. Neurofibromatosis type 1 (NF1) is an ...

Atypical non-[99mTc]Tc-MIBI avid parathyroid adenoma with a sternal brown tumor, mimicking ectopic parathyroid adenoma in planar and SPECT images: Importance of SPECT/CT acquisition

Primary hyperparathyroidism (pHPT) is defined by the excess level of parathyroid hormone (PTH). Parathyroid adenoma is responsible for about 80% of all pHPT. Parathyroid adenoma with cystic feature and atypical pathology is recognized as a rare entity. Technetium-99m methoxy isobutyl isonitrile ([99mTc]Tc-MIBI) scintigraphy has favorable detection rate for ectopic gland as well as th...